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KMID : 1140120060110030235
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Cancer Prevention Research
2006 Volume.11 No. 3 p.235 ~ p.239
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Screening of Antioxidant and Anticancer Effects from Flavonoids
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Kang Kyoung-Ah
Zhang Rui
Piao Mei Jing
Park So-Yoon
Park Jinny
Kim Ju-Sun
Kang Sam-Sik
Hyun Jin-Won
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Abstract
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Reactive oxygen species (ROS) such as hydrogen peroxide, superoxide anion, and hydroxyl radical lead to damages of cellular molecules and are a cause of cancer. To find the anticancer compounds that scavenge the ROS, we have screened the antioxidant effect against DPPH radical and H2O2 induced oxidative stress from 39 flavonoids at 10μg/ml. (+)-Catechin and epicatechin at 10μg/ml were found to scavenge DPPH radical and intracellular ROS. We also investigated whether two compounds may show anticancer effect against cancer cells by MTT reduction assay. As a result, epicatechin showed the strongest cytotoxicity to U937 cells among NCI-H460, HeLa, U937, and MCF-7 cells.
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KEYWORD
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Oxidative stress, Reactive oxygen species, Anticancer
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